In vivo

Truly Labs provides a number of different animal models and technologies. We use defined protocols or adjust and modify protocols based on specific scientific questions that are to be addressed.

Pharmacokinetic (PK) studies

We generate pharmacokinetic profiles in an individual animal, creating high robustness in your data. We can assist you with bioanalysis and ensure the best PK parameter determination using the industry-standard software Phoenix® WinNonlin®

Customized pharmacodynamics (PD) models

A good PD model can provide pivotal information for understanding the efficacy, dose-response and time-effects of a drug. PD makers can often continue to serve as early target engagement biomarkers in man.

Modeling of PK/PD relationships and dose predictions

A better understanding of the PK/PD relationship of your compound will provide key information for successful preclinical development and clinical design e.g. dose to man prediction.

Administration routes and proper formulation

Delivery route and drug formulation is of key importance for success. We perform in vivo studies using most administration routes in rodents, including inhalation. Through close collaboration with formulation experts we can ensure optimal formulation of your drug.

Examples of animal models

  • Acute & Chronic LPS models
  • Air Pouch model
  • Tumor models (incl. Xenograft models)
  • Gastrointestinal models of diarrhea
  • Surgical interventions